Tribute to Emory Cardiology

Research in the Emory Cardiology Division has demonstrated a crucial role for oxidative stress in both atherosclerosis and hypertension. Major contributions have been made regarding the molecular mechanisms underlying both the generation and effects of reactive oxygen species in the vessel. State of the art methodology for studies of cultured cells, intact vessels, and animal models are routinely used. Methods for detection of reactive oxygen species include chemiluminescence, fluorescent and spectrophotometric techniques, Electron Spin Resonance Spectroscopy, and confocal microscopy. Consequences of oxidative stress in cells and animal models are examined using molecular approaches including enzyme activity, gene expression and gene regulation. Adenoviral approaches are used to overexpress antioxidant enzymes in cultured cells. Genetically altered mice, many made in the Emory Cardiology Division, are used to examine the effect of oxidative stress on physiological function and pathophysiological states. Other animal models include hypertensive rats and hypercholesterolemic rabbits. Note: This is the unofficial web tribute to Emory Cardiology that has been put together as a token of gratitude for the exceptional training that Dr. Chung had received as a cardiology fellow (1997-2001). Copyright © 1998-2007 Andrew B. Chung, M.D., Ph.D. All rights reserved. Date of last update: 11/20/2008